Endocrine Abstracts

Aim: We have proposed to study the modulation of the Notch pathway in diabetes having in mind the essential role played by the Notch system in the regulation of cell differentiation and angiogenesis.Methods: The effect of hyperglycemia on Notch system was studied in vitro and in vivo using western blot, reporter gene assay or evaluation of target genes (qRT-PCR). The functional consequences of the Notch system modulation were studied by the...

Diabetic wounds represent a medical and economical burden with a high need to develop more efficient therapies.Estrogens have a positive effect on cutaneous wound healing. Their decreased levels could count for impaired wound healing in elderly. The biological estrogen’s effects are mediated by two nuclear receptors subtypes (ERα and ERβ) and they were differently implied for the wound healing benefic processes. However, the estrogen effec...